Biochem/physiol Actions
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary TargetEffective transport of GSH-MEE
General description
Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Effective transport of GSH-MEE has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. A protective agent against cellular damage, such as cataracts and mitochondrial degeneration.
Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases to release GSH. Effective transport of GSH-MEE has been used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals. A protective agent against cellular damage such as in cataracts and mitochondrial degeneration.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Grattagliano, I., et al. 1995. J. Pharmacol. Exp. Ther. 272, 484.Martensson, J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 317.Anderson, M.E., and Meister, A. 1989. Anal. Biochem. 183, 16.Anderson, M.E., et al. 1985. Arch. Biochem. Biophys. 239, 538.Wellner, V.P., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 4732.Puri, R.N., and Meister, A. 1983. Proc. Natl. Acad. Sci. USA 80, 5258.
Packaging
Packaged under inert gas
50 mg in Glass bottle
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: