Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetEffective transport of GSH-MEE

General description

Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Effective transport of GSH-MEE has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. A protective agent against cellular damage, such as cataracts and mitochondrial degeneration.

Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases to release GSH. Effective transport of GSH-MEE has been used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals. A protective agent against cellular damage such as in cataracts and mitochondrial degeneration.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Grattagliano, I., et al. 1995. J. Pharmacol. Exp. Ther. 272, 484.Martensson, J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 317.Anderson, M.E., and Meister, A. 1989. Anal. Biochem. 183, 16.Anderson, M.E., et al. 1985. Arch. Biochem. Biophys. 239, 538.Wellner, V.P., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 4732.Puri, R.N., and Meister, A. 1983. Proc. Natl. Acad. Sci. USA 80, 5258.

Packaging

Packaged under inert gas

50 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.

Warning

Toxicity: Standard Handling (A)